B!SON: A Tool for Open Access Journal Recommendation

Finding a suitable open access journal to publish scientific work is a complex task: Researchers have to navigate a constantly growing number of journals, institutional agreements with publishers, funders’ conditions and the risk of Predatory Publishers. To help with these challenges, we introduce a web-based journal recommendation system called B!SON. It is developed based on a systematic requirements analysis, built on open data, gives publisher-independent recommendations and works across domains. It suggests open access journals based on title, abstract and references provided by the user. The recommendation quality has been evaluated using a large test set of 10,000 articles. Development by two German scientific libraries ensures the longevity of the project

Comparing different search methods for the open access journal recommendation tool B!SON

Finding a suitable open access journal to publish academic work is a complex task: Researchers have to navigate a constantly growing number of journals, institutional agreements with publishers, funders’ conditions and the risk of predatory publishers. To help with these challenges, we introduce a web-based journal recommendation system called B!SON. A systematic requirements analysis was conducted in the form of a survey. The developed tool suggests open access journals based on title, abstract and references provided by the user. The recommendations are built on open data, publisher-independent and work across domains and languages. Transparency is provided by its open source nature, an open application programming interface (API) and by specifying which matches the shown recommendations are based on. The recommendation quality has been evaluated using two different evaluation techniques, including several new recommendation methods. We were able to improve the results from our previous paper with a pre-trained transformer model. The beta version of the tool received positive feedback from the community and in several test sessions. We developed a recommendation system for open access journals to help researchers find a suitable journal. The open tool has been extensively tested, and we found possible improvements for our current recommendation technique. Development by two German academic libraries ensures the longevity and sustainability of the system.German Federal Ministry of Education and Research (BMBF)/Projekt DEAL/16TOA034A/E

I see you remembering: What eye movements can reveal about process characteristics of prospective memory

Prospective memory performance describes the delayed execution of an intended action. As this requires a mixture of memory and attentional control functions, current research aims at delineating the specific processes associated with solving a prospective memory task. Therefore, the current study measured, analysed and compared eye movements of participants who performed a prospective memory, a free viewing, and a visual search task. By keeping constant the prospective memory cue as well as the context of tasks, we aimed at putting the processes of solving prospective memory tasks into context. The results show, that when a prospective memory task is missed, the continuous gaze behaviour is rather similar to the gaze behaviour during free viewing. When the prospective memory task is successfully solved, on the other hand, average gaze behaviour is between free viewing and visual search. Furthermore, individual differences in eye movements were found between low and high performers. Our data suggest that a prospective memory task can be solved in different ways, therefore different processes can be observed

Acinar cell carcinoma of the pancreas: a rare disease with different diagnostic and therapeutic implications than ductal adenocarcinoma

Acinar cell carcinoma (ACC) of the pancreas is a very rare cancer, constituting 1 % of all malignant non-endocrine pancreatic tumors. Only very limited data exist to guide treatment in patients with advanced ACC. Between 2000 and 2015, 15 patients with ACC were diagnosed and/or treated at our high-volume comprehensive cancer center. Medical records and correlating serum levels of the potential serum tumor markers CA 19-9, CEA and lipase were analyzed retrospectively. A substantial antitumor activity was observed for treatment regimens containing 5-FU and oxaliplatin with partial responses or prolonged disease stabilizations (> 12 months) observed in 6 out of 7 patients (86 %). Activity was also observed for single-agent 5-FU and its oral prodrugs. Serum lipase levels were elevated in 7 of 12 patients with advanced disease (58 %), whereas CEA and CA 19-9 seemed to be of minor importance for ACC (elevated pre-treatment levels in 4/12 and 3/12 cases, respectively). In selected patients, repeated serum lipase measurements were available and accurately predicted response to chemotherapy and relapse after surgery. 5-FU- and oxaliplatin-containing regimens are active in advanced ACC. Lipase kinetics may be a useful novel tool to monitor the course of disease as well as treatment effects in ACC

Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories

Identifying the earliest somatic changes in prostate cancer can give important insights into tumor evolution and aids in stratifying high- from low-risk disease. We integrated whole genome, transcriptome and methylome analysis of early-onset prostate cancers (diagnosis ≤55 years). Characterization across 292 prostate cancer genomes revealed age-related genomic alterations and a clock-like enzymatic-driven mutational process contributing to the earliest mutations in prostate cancer patients. Our integrative analysis identified four molecular subgroups, including a particularly aggressive subgroup with recurrent duplications associated with increased expression of ESRP1, which we validate in 12,000 tissue microarray tumors. Finally, we combined the patterns of molecular co-occurrence and risk-based subgroup information to deconvolve the molecular and clinical trajectories of prostate cancer from single patient samples

Dual Actin-bundling and Protein Kinase C-binding Activities of Fascin Regulate Carcinoma Cell Migration Downstream of Rac and Contribute to Metastasis

Recurrence of carcinomas due to cells that migrate away from the primary tumor is a major problem in cancer treatment. Immunohistochemical analyses of human carcinomas have consistently correlated up-regulation of the actin-bundling protein fascin with a clinically aggressive phenotype and poor prognosis. To understand the functional and mechanistic contributions of fascin, we undertook inducible short hairpin RNA (shRNA) knockdown of fascin in human colon carcinoma cells derived from an aggressive primary tumor. Fascin-depletion led to decreased numbers of filopodia and altered morphology of cell protrusions, decreased Rac-dependent migration on laminin, decreased turnover of focal adhesions, and, in vivo, decreased xenograft tumor development and metastasis. cDNA rescue of fascin shRNA-knockdown cells with wild-type green fluorescent protein-fascin or fascins mutated at the protein kinase C (PKC) phosphorylation site revealed that both the actin-bundling and active PKC-binding activities of fascin are required for the organization of filopodial protrusions, Rac-dependent migration, and tumor metastasis. Thus, fascin contributes to carcinoma migration and metastasis through dual pathways that impact on multiple subcellular structures needed for cell migration